Local anaesthetic creams.

Developments in local anaesthetic drugs.

Most of the recent developments in local anaesthetics have been a direct consequence of the recognition, 20 yr ago, of the acute, life-threatening cardiotoxicity of bupivacaine. All local anaesthetics produce a dose dependent delay in the transmission of impulses through the cardiac conduction system by their action on the cardiac sodium and potassium channels. However, overt cardiotoxicity usu...

Local Anaesthetic Pharmacology 11 / 07 / 05

Local anaesthetic drugs are used widely for the provision of anaesthesia and analgesia both intraand post-operatively. Understanding the pharmacology of these agents as a group, as well as the differences between specific drugs, enables the anaesthetist to use them safely to maximum effect. This tutorial focuses on the basic structure and function of local anaesthetics. Learning will be improve...

Local anaesthetic administration for IUD/IUS insertions.

Allergic reaction to an amide local anaesthetic.

A 67-yr-old female patient gave a history of allergy to lignocaine. When she was challenge-tested with the intradermal injection of 0.5% bupivacaine 0.2ml she had a systemic reaction. This reaction was accompanied by a decrease in the concentration of complement C4 in the plasma, which indicated that the reaction was immunologically-mediated. This is the first report of allergy to a local anaes...

Option of local anaesthetic for IUD fittings.